Endocrine Abstracts

Aim of the study was1. To assess the thyroid function in pregnancy in the course of effective iodine prophylaxis model introduced in 1997, based on obligatory salt iodization.2. To exam glucose tolerance and insulinemia in pregnancy.Methods: TSH, fT4, aTPO, urine iodine concentration, usg thyroid volume and homogeneity, glucose and insulin during OGTT, blood pressure, BMI, and thyroid function and glucose met...

Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight. In AN, similarly to syndromes of lipodystrophy, one observes the significant loss of the adipose tissue. In lipodystrophies, despite the lack of subcutaneous adipose tissue, insulin resistance is observed. Adipose tissue is known as a source of a variety of bioactive peptides, known as adipocytokines. The aim of the present study was to examine the plasma concentration of adipocytokines in relation...

Introduction: Neuroendocrine tumors secreting ACTH are a rare cause of Cushing’s syndrome.Diagnostic and therapeutical difficiulties might be caused due to different clinical picture of of neuroendocrine tumors.Patients, diagnostic and therapeutic approach: During 2004–2005 2 female patients 32-years old AL and 67-years old ZS were hospitalized in Endocrinology Department due to severe hypercorticism signs and symptoms. I...

Visfatin is a newly discovered protein secreted by adipose tissue, which is suggested to play a role in pathogenesis of insulin resistance. Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. The aim of the present study was to asses the relation between serum visfatin and insulin sensitivity and markers of hyperandrogenism in a lean and obese PCOS patients. The stud...

The pathogenesis of insulin resistance is not completely understood, however, there are data that it might be associated with altered tissue carbohydrate and lipid oxidation. Adiponectin may be a key regulator of insulin sensitivity and energy metabolism. The aim of the present study was to determine the association of adiponectin, glucose metabolism (oxidation and storage) and lipid oxidation by applying the euglycemic clamp technique and indirect calorimetry.<p class="ab...

Hypoglycaemia stimulation serves as a model of physiological function of adrenal action during the stress reaction. The study aimed to describe the differences of steroid response between hypoglycemia and various doses of Synacthen (as ACTH stimulation alone). The goal of the study was to investigate the physiology of adrenal response. Twenty four steroids were measured in plasma using gas chromatography - mass spectrometry after stimulation of 1 μg, 10 μg and 250 &#...

The adrenal androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, 5-androstenediol and 11β-hydroxy-androstenedione have a wide spectrum of important physiological effects. Aim of our study was to find differences in reaction of the C19 Δ5-steroids between healthy women and patients with adrenal insufficiency in various doses of Synacthen (1 ug, 10 ug and 250 ug). Our study involved seven healthy women and six premenopausal females (BMI an...

Objective: Smoking during pregnancy could have impact on steroidogenesis, with more marked changes in smokers carrying boys as well as in their newborns. The aim of study was compared steroid hormones between non-smokers, ex-smokers, which stop smoking in the beginning of pregnancy, and active smokers.Method: We focused on changes in steroidogenesis in the blood of mothers in their 37th week of pregnancy and in mixed cord blood from their newb...

Our understanding of modifiable risk factors for developing primary hyperparathyroidism (PHPT) may support interventions to prevent the development of the disease or reduce its severity and deepen our insights into its pathogenesis. Obesity has been associated with elevated serum parathyroid hormone (PTH) in the general population and may also alter the clinical presentation in patients with PHPT.Objectives: The objectives of the study were to compare th...

The reference ranges of thyroid function tests during pregnancy are still being debated, even in ethnically homogenous populations. The defining of the normal range is of importance, as it influences therapeutic decisions, particularly the use (or over-use) of levothyroxine in this vulnerable population. The study was aimed at the longitudinal assessment of thyroid function tests results in marginally iodine sufficient Polish population of pregnant women. The study was perform...